Did you know OVER 70% of statin-intolerant patients CAN actually take a statin?
Consider this stepwise approach when patients report myalgias:
- Evaluate other causes of muscle symptoms such as physical activity, vitamin D deficiency, hypothyroidism, rheumatologic or musculoskeletal disease, alcohol or drug abuse, and or other causes of leg cramps.
- Avoid interacting medication such as macrolides and fibrates. Also, consider other medications that could be causing myopathies such as steroids, antipsychotics, immunosuppressives, protease inhibitors, and bisphosphonates.
- Consider suggesting a “statin holiday” where the statin is held for a few weeks. If the symptoms persist, rule out the statin as the cause.
- Switch to another low-dose statin, then titrate. Choose rosuvastatin or pravastatin for fewer interactions.
- Choose a statin with a longer half-life (rosuvastatin or atorvastatin) and try alternate-day or twice-weekly dosing if other options fail.
Identify TRUE Statin Intolerances using an App
The American College of Cardiology statin intolerance app.